Renal Toxicity

OVERVIEW

GUIDELINES

Renal – Nephritis2

f Treat until symptoms improve to Grade 1, then taper over 4-6 weeks.

Renal – Nephritis1

Renal – Nephritis3

INCIDENCE

Pembrolizumab: imAE Incidence and Management in Clinical Trials – Nephritis4

Immune-mediated Nephritis

ONSET & DURATION

Pembrolizumab: imAE Incidence and Management in Clinical Trials – Nephritis4

IMMUNE-RELATED NEPHRITIS IN PATIENTS TREATED WITH PEMBROLIZUMAB (N=9/2,799)4

References:

  1. Schneider BJ, Naidoo J, Santomasso BD, Lacchetti C, Adkins S, Anadkat M, et al. Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: ASCO guideline update. Journal of clinical oncology. 2021;39(36):4073-126
  2. NCCN (National Comprehensive Cancer Network) V.1.2023. Accessed at: https://www.nccn.org/professionals/physician_gls/pdf/immunotherapy.pdf. Last accessed: 1-5-2023
  3. Haanen J, Obeid M, Spain L, Carbonnel F, Wang Y, Robert C, et al. Management of toxicities from immunotherapy: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Annals of Oncology. 2022;33(12):1217-38.
  4. Egyptian drug authority KEYTRUDA® leaflet approval date: 23/05/2023

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